HEALTH EFFECTS 11) TITLE: Mechanisms of Cardiopulmonary Injury Caused by Mobile Source- Generated Fine and Ultrafine Particles
ثبت نشده
چکیده
PROBLEM: There are strong associations between exposures to motor vehicle-derived particles and cardiopulmonary morbidity and mortality but there have been few studies that realistically examined possible differences in the effects of gasoline versus diesel-powered engine emissions. The Caldecott Tunnel, which has segregated traffic patterns, offers an opportunity to test the hypothesis that the health effects of diesel particles can be differentiated from those of gasoline particles with real world particles. Bore 1 is used by a mix of light-duty (LDV) and heavy-duty vehicles (HDV) while bore 2 is almost exclusively (99.8 percent) LDV (Gross, et al., Atmos. Sci. and Tech. 32: 152-163, 2000).
منابع مشابه
Human pulmonary responses to experimental inhalation of high concentration fine and ultrafine magnesium oxide particles.
Exposure to air polluted with particles less than 2.5 micron in size is associated epidemiologically with adverse cardiopulmonary health consequences in humans. The goal of this study was to characterize human pulmonary responses to controlled experimental high-dose exposure to fine and ultrafine magnesium oxide particles. We quantified bronchoalveolar lavage (BAL) cell and cytokine concentrati...
متن کاملIncreased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types.
BACKGROUND Ultrafine particles have been hypothesised to be an important contributing factor in the toxicity and adverse health effects of particulate air pollution (PM10) and nanoparticles are used increasingly in industrial processes. AIMS To compare the ability of ultrafine and fine particles of titanium dioxide and carbon black to induce inflammation, cause epithelial injury, and affect t...
متن کاملAir pollution and retained particles in the lung.
Epidemiologic evidence associates particulate air pollution with cardiopulmonary morbidity and mortality. The biological mechanisms underlying these associations and the relationship between ambient levels and retained particles in the lung remain uncertain. We examined the parenchymal particle content of 11 autopsy lungs from never-smoking female residents of Mexico City, a region with high am...
متن کاملUltrafine particles in urban air and respiratory health among adult asthmatics.
Airborne particles are associated with adverse health effects and contribute to excess mortality in epidemiological studies. A recent hypothesis proposes that the high numbers of ultrafine (<0.1 microm diameter) particles in ambient air might provoke alveolar inflammation and subsequently cause exacerbations in pre-existing cardiopulmonary diseases. To test the hypothesis adult asthmatics were ...
متن کاملCorrelation between particle size, in vivo particle persistence, and lung injury.
Dosimetry parameters such as deposition, clearance, retention, and translocation and dissolution of inhaled particles in and to different lung compartments may be important for the persistence of particles in the lung and may correlate with adverse pulmonary effects. We investigated such correlations using a model involving TiO2 particles of two particle sizes (20 nm diameter, ultrafine; 250 nm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006